OpenFederal grantOpen to for-profit businessesPAR-25-182

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Oct 15, 2027(367 days left)

Does this fit your business?

This is an NIH research grant for developing and testing new psychosocial therapies and preventive interventions for mental disorders, requiring a clinical trial. It suits research-driven organizations such as universities, health systems, and behavioral health R&D firms. Businesses with no research or clinical trial capability, or those in unrelated fields like construction or agriculture, should not bother applying.

Best for
Universities and academic research teams running mental health clinical trials, Nonprofits and community or faith-based organizations developing psychosocial interventions, Small businesses and for-profits with R&D capacity in behavioral health, Tribal, state, and local government entities pursuing mental health intervention research
Not for
Businesses outside behavioral health research, such as construction, transportation, or agriculture firms, Organizations seeking general operating funds or direct service delivery money rather than research funding
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
74
Good Match
Social Services & NonprofitMatches your industry (social)
70
Good Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
53
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
51
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
51
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is October 15, 2027.
Who can apply for this grant?
A wide range of entities can apply, including small businesses, for-profit organizations, nonprofits with or without 501(c)(3) status, institutions of higher education, state and local governments, school districts, public housing authorities, and federally recognized and other Native American tribal organizations. Faith-based and community organizations, foreign organizations, and certain minority-serving institutions are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses are listed as eligible, but the notice does not publish rules about business structure, so you would need to confirm with NIH.
Can a nonprofit apply?
Yes. Nonprofits both with and without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NIMH R61/R33 clinical trial grants to develop and test novel psychosocial therapeutic and preventive interventions for mental disorders. Open to universities, nonprofits, governments, tribes, faith/community organizations, and for-profit organizations including small businesses; funds pilot research and clinical trial phases.

About this grant

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Mental health
  • Research
  • Behavioral science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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