OpenFederal grantOpen to for-profit businessesPAR-25-026

NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Jan 7, 2027(86 days left)

Does this fit your business?

This is an NIH research grant for Phase I clinical trials of diagnostics and therapeutics for heart, lung, blood, and sleep disorders, including final preclinical trial-preparation work. It fits small biotech and medical research organizations with a therapeutic or diagnostic candidate ready for early human testing. If you are not running clinical research in those disease areas, do not apply.

Best for
Small biotech and medical device companies with a therapeutic or diagnostic ready for a Phase I trial, Universities and academic medical centers running investigator-initiated HLBS trials, Nonprofits and research institutes with clinical trial programs, Hospitals and health systems affiliated with eligible institutions
Not for
Retail, finance, housing, or any business outside heart, lung, blood, and sleep clinical research, Companies with no therapeutic or diagnostic candidate and no clinical trial plan, Organizations seeking general operating or business expansion funding
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
79
Strong Match
Education & TrainingMatches your industry (training)
69
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2027.
Who can apply for this grant?
Small businesses, for-profit firms, nonprofits, private and public universities, state, county, city and tribal governments, independent school districts, public housing authorities, and certain other entities such as foreign organizations, HBCUs, Hispanic-serving institutions, and Alaska Native/Native Hawaiian serving institutions. NIH lists the full eligibility codes in the notice.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not publish how sole proprietors or single-member LLCs are treated, so check the full NOFO or contact NIH before counting on it.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without it (other than institutions of higher education) are both listed as eligible, and faith-based and community-based organizations are also named.

Summary

NIH (NHLBI) funds investigator-initiated Phase I clinical trials of diagnostic and therapeutic interventions for heart, lung, blood, and sleep disorders, including final preclinical trial-preparation activities. Eligible applicants include small businesses, for-profit firms, nonprofits, universities, and state/local/tribal governments; foreign entities may also apply.

About this grant

The objective of this funding opportunity is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. In addition to supporting clinical trial start-up and implementation activities, this FOA will provide support for final stage preclinical activities needed for the implementation of the proposed trial. All the activities proposed in the R61 phase must be directly related to the therapeutic/diagnostic in preparation for the clinical trial. The proposed trial can be single or multisite. This NOFO will utilize a bi-phasic, milestone-driven mechanism of award where the first phase can be used to finalize required pre-trial activities such as stability, shipping studies, and site training.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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