OpenFederal grantOpen to for-profit businessesPAR-25-188

NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

National Institutes of HealthCloses Jan 6, 2028(450 days left)Up to $500,000

Does this fit your business?

This NIH program funds planning and implementation of behavioral or social intervention clinical trials targeting dental, oral, or craniofacial conditions. It is for research-capable organizations, not businesses looking for general operating money. Retail, finance, and housing organizations should not bother applying.

Best for
Healthcare and biotech organizations running behavioral or social intervention clinical trials on dental, oral, or cran, Research organizations and universities with clinical trial experience, Nonprofits and community organizations partnering on oral health intervention studies, Small businesses developing behavioral health interventions for dental, oral, or craniofacial conditions
Not for
Retail, finance, housing, and other businesses with no connection to health research, Organizations without research or clinical trial capability, Foreign entities
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
85
Strong Match
Education & TrainingMatches your industry (training, stem)
79
Strong Match
Social Services & NonprofitMatches your industry (social)
73
Good Match
Transportation & LogisticsMatches your industry (transit)
65
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $500,000

Questions about this grant

When is the application deadline?
The application deadline is January 6, 2028.
How much funding can an applicant receive?
The largest award is $500,000. The funding supports a two-phase structure: an initial planning phase (UG3) of up to 2 years, with possible transition to an implementation phase (UH3) of up to 5 years.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), institutions of higher education, state, county, city, and tribal governments, independent school districts, special district governments, public housing authorities, and certain other organizations. Foreign entities are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations are listed as eligible, but the notice does not break down business structure requirements.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are eligible, as long as they are not institutions of higher education.

Summary

NIH cooperative agreement funding a two-phase UG3/UH3 award to plan and then implement behavioral or social intervention clinical trials targeting dental, oral, or craniofacial conditions. Eligible applicants include small businesses, other for-profits, nonprofits, universities, state/local/tribal governments, and other organizations; foreign entities are excluded. Ceiling $500,000.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage UG3/UH3 phased cooperative agreement research applications to plan and implement behavioral and social intervention clinical trials. Studies appropriate for this announcement include clinical trials to develop and test behavior change interventions related to dental, oral, or craniofacial conditions. Awards made under this FOA will initially support a milestone-driven planning phase (UG3) for up to 2 years, with possible transition to a clinical trial implementation phase (UH3) of up to five years. Only UG3 projects that have met the scientific milestones and feasibility requirements may transition to the UH3 phase. The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA. The UG3 phase will permit both scientific and operational planning activities. Scientific planning activities include small-scale data collection to assess the feasibility and/or acceptability of a planned behavioral or social intervention and associated study procedures (e.g., acceptability of study content or mode of delivery; feasibility of proposed data collection procedures; preliminary testing of intervention training and fidelity monitoring procedures). Operational planning activities include, at a minimum, development of: the final clinical protocol; the intervention manual or equivalent; the data management system and other tools for data and quality management, safety and operational oversight plans; recruitment and retention strategies; and other essential documents. The UH3 phase will support the conduct of investigator-initiated intervention research at all stages, from early mechanistic research and intervention development (e.g., Stages 0/ I) through implementation and cost-effectiveness research (Stages IV/V).

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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