OpenFederal grantOpen to for-profit businessesPAR-25-025

NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)

National Institutes of HealthCloses Jan 7, 2027(86 days left)Up to $1,515,000

Does this fit your business?

This is an NIH R33 cooperative agreement for phase I clinical trials of diagnostic or therapeutic interventions for heart, lung, blood, and sleep disorders. It is for organizations that already have a trial designed and regulatory approvals (FDA, DSMB, IRB) in hand, because the trial must start in the first quarter of the project period. If you are not running clinical research in HLBS disorders, or you still need pre-clinical and trial-readiness support, do not apply here.

Best for
Small businesses and for-profits running phase I clinical trials for heart, lung, blood, or sleep diagnostics or therap, Universities, hospitals, and academic medical centers with trial teams and IRB/FDA approvals in hand, Nonprofits and faith- or community-based organizations with clinical research capacity, State, local, and tribal governments with health research programs
Not for
Businesses outside healthcare and biotech with no clinical trial capability, Organizations that cannot start a clinical trial within the first quarter of the project period, Foreign or non-U.S. entities
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
87
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Clinical trials, Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $1,515,000

Questions about this grant

When is the application deadline?
January 7, 2027.
How much funding can an applicant receive?
The largest award listed is $1,515,000. No other award amounts are published.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), private and public institutions of higher education, state, county, city, township, special district, and independent school district governments, federally recognized tribal governments and tribal organizations, and public housing authorities. Faith-based and community-based organizations are also eligible. Foreign entities may not apply, though non-domestic components of U.S. organizations are allowed.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not publish rules for sole proprietors or single-member LLCs specifically.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible applicants.

Summary

NIH R33 cooperative agreement supporting phase I clinical trials of diagnostic and therapeutic interventions for heart, lung, blood, and sleep disorders in adults and children. Eligible applicants include small businesses, for-profits, universities, nonprofits, state/local/tribal governments, and faith-based organizations; foreign entities may not apply.

About this grant

The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. The proposed trial can be single or multisite. Applicants applying for funding under this NOFO should be ready to initiate the clinical trial within the first quarter of the project period. Discussion, submission, and attainment of applicable regulatory (FDA, DSMB, IRB) approvals, and establishment of drug (and placebo, if applicable) supplies, and any necessary third-party agreements should be established by the time of award. If time and support for these and other pre-clinical and/or trial readiness activities are desired, applicants should consider the companion NOFO which utilizes an R61/R33 phased approach.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Clinical research
  • Therapeutics
  • Diagnostics

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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