OpenFederal grantOpen to for-profit businessesPAR-25-081

National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)

National Institutes of HealthCloses Jan 7, 2027(86 days left)Up to $499,999

Does this fit your business?

This is an NCI research grant for running early-phase (Phase 0, I, II) clinical trials in cancer treatment or diagnosis, open to small businesses, for-profits, nonprofits, governments, tribes, and universities. If your organization does not run or directly support clinical cancer research, this is not your program. The money funds the trial itself, not general business operations.

Best for
Small biotech and life-science companies running early-phase cancer trials, Cancer centers and research hospitals, Universities and academic medical centers, Nonprofits focused on cancer research
Not for
Businesses outside cancer research and clinical trials, Organizations that cannot run or partner on a clinical trial, Applicants seeking funding for unrelated products or services
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
82
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $499,999

Questions about this grant

When is the application deadline?
January 7, 2027.
How much funding can an applicant receive?
The largest single award is $499,999, and total program funding is also listed at $499,999. No other award amounts are published.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), city, county, state, and tribal governments, public housing authorities, independent school districts, and institutions of higher education can apply. Foreign entities, faith-based and community-based organizations, and certain serving institutions are also eligible. Whatever your organization type, the project itself must include at least one early-phase (Phase 0, I, or II) clinical trial in cancer treatment or diagnosis.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Sole proprietors and single-member LLCs are not named in the eligibility list, so their eligibility is not published here.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NCI funds investigator-initiated early phase (Phase 0, I, II) clinical trials for cancer treatment and diagnosis. Eligible applicants include small businesses, for-profit organizations, nonprofits, governments, tribes, and institutions of higher education; foreign entities may also apply. Funds support conducting clinical trials, alone or with other research aims.

About this grant

Through this Notice of Funding Opportunity, the National Cancer Institute (NCI) seeks research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM. The proposed project must involve at least 1 clinical trial related to the scientific interests of one or more of the following research programs: Cancer Therapy Evaluation Program, Cancer Imaging Program, Cancer Diagnosis Program, Radiation Research Program, Complementary and Alternative Medicine Program and/or the HIV and AIDS Malignancies Research Programs. Applicants may propose to conduct an early phase trial by itself, or in combination with another research aim(s) as appropriate.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Cancer research
  • Clinical trials

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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