OpenFederal grantOpen to for-profit businessesPAR-25-185

Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH R01 research grant for scientists who screen and functionally validate genetic variants linked to congenital anomalies, intellectual developmental disabilities, and inborn errors of metabolism, using databases, animal models, or in vitro systems. It is for organizations with genomics research capability, not for companies seeking commercialization or operating capital. Retail, construction, finance, and any applicant without a research program should not bother.

Best for
Universities and academic research labs, Nonprofits and research institutes running genomics studies, Biotech and genomics companies with R&D capacity, Government and tribal entities with research programs
Not for
Businesses with no genomics or biomedical research capability, Organizations looking for general operating or commercialization funding, Applicants outside the research fields this R01 targets
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
75
Strong Match
Technology & SoftwareMatches your industry (tech)
72
Good Match
Education & TrainingMatches your industry (stem)
66
Good Match
Social Services & NonprofitMatches your industry (community)
65
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2028.
Who can apply for this grant?
Universities, nonprofits, small and other for-profit businesses, state, local, and tribal governments, public housing authorities, independent school districts, and certain foreign organizations. NIH also lists faith-based and community-based organizations, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges as eligible.
Can a sole proprietor or single-member LLC apply?
The listing does not say. Small businesses are eligible, but the facts do not specify whether a sole proprietor or single-member LLC qualifies as one for this program, so check with NIH before counting on it.
Can a nonprofit apply?
Yes. Both 501(c)(3) and non-501(c)(3) nonprofits can apply, though institutions of higher education are treated under their own category.

Summary

NIH R01 grants to screen and functionally validate genetic variants linked to human congenital anomalies, intellectual developmental disabilities, and inborn errors of metabolism using databases, animal models, and in vitro systems. Eligible: universities, nonprofits, small and other for-profit businesses, governments, tribes, and some foreign entities.

About this grant

Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Genomics
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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