OpenFederal grantOpen to for-profit businessesPAR-25-282

Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH research grant (R21) for translational studies of mood and psychotic disorders, such as perimenopausal depression, anxiety, bipolar disorder, and schizophrenia, during the menopause transition. It funds research aimed at finding targets for future treatments, not services, product launches, or general operations. If your organization does not conduct hypothesis-driven biomedical or behavioral research, do not apply.

Best for
Research teams studying mood or psychosis during the menopause transition, Universities and academic medical centers, Small biotech or health research businesses, Nonprofits and government or tribal health agencies
Not for
Businesses with no research capability, Organizations outside health, mental health, or women's health research
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
70
Good Match
Social Services & NonprofitMatches your industry (social)
66
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsMatches your industry (transit)
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
53
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
53
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
52
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2028.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, state, county, city, township, special district, and independent school district governments, federally recognized tribal governments, tribal organizations, and public housing authorities. The eligibility text also lists Alaska Native and Native Hawaiian Serving Institutions, AANAPISISs, federal agencies, faith-based and community-based organizations, Hispanic-serving institutions, HBCUs, non-U.S. entities, regional organizations, TCCUs, and U.S. territories or possessions.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligible applicant codes list small businesses and for-profit organizations generally, but they do not specifically name sole proprietors or single-member LLCs, so check the full notice before assuming you qualify.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are listed as eligible, other than institutions of higher education.

Summary

NIH R21 grants for translational research on mood and psychotic disorders (e.g., perimenopausal depression, anxiety, bipolar disorder, schizophrenia) during the menopause transition, studying neurobiological and behavioral mechanisms to identify targets for future treatments. Eligible applicants include small businesses, for-profits, universities, nonprofits, and state/local/tribal governments; no

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the MT. Aspects of mood and psychosis disorders that are of interest include: classic depressive symptoms in combination with menopause symptoms (e.g., hot flashes, night sweats, sleep disturbance) and psychological challenges, the role of reproductive steroids in the regulation of mood and behavior during the MT, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, appreciation of psychosocial factors common in midlife, and differential diagnoses. Review criteria will focus on the comprehensiveness of the neurobiology and mechanisms of action underlying mood and psychosis symptoms and hypothesis-driven work.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Mental health
  • Women health
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry