OpenFederal grantOpen to for-profit businessesPAR-25-210

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

National Institutes of HealthCloses Jun 2, 2027(232 days left)

Does this fit your business?

This is an NIH research grant for mechanistic studies of precision probiotic therapies—specifically, projects with preliminary data on host biological patterns that predict probiotic response, now needing rigorous animal-model or human-subject studies to test causality. It fits biotech and life-science research organizations, including small businesses with research capacity. Retail, finance, housing, and other businesses outside health research should not bother; neither should anyone without a

Best for
Biotech and life-science companies with preliminary data on probiotic response markers, Universities and academic research teams running mechanistic studies, Nonprofits and research institutes focused on microbiome or clinical research, Small businesses doing R&D on precision probiotic therapies
Not for
Retail, e-commerce, finance, housing, or other businesses outside health and biotech, Companies without preliminary data on host biological patterns linked to probiotic response, Foreign organizations or U.S. organizations with non-U.S. components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
85
Strong Match
Education & TrainingMatches your industry (stem)
71
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Colleges and universities, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
June 2, 2027.
Who can apply for this grant?
Small businesses, for-profit companies, nonprofits (with or without 501(c)(3) status), universities, state, local, county and tribal governments, public housing authorities, independent school districts, special district governments, federal agencies, and certain serving institutions such as HBCUs and Hispanic-serving institutions. Foreign organizations and non-U.S. components of U.S. organizations may not apply.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full notice or contact NIH before assuming you are eligible.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without it may apply, as long as they are not institutions of higher education (those are covered under a separate eligible category).

Summary

NIH R33 grant funding mechanistic research on precision probiotic therapies—studies identifying host biological patterns that predict probiotic response, using animal models or human subjects. Eligible applicants include small businesses, for-profits, nonprofits, universities, state/local/tribal governments, and federal agencies; foreign entities may not apply.

About this grant

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology (e.g., native microbiome, immune system, gender, diet, age, genetic background, lifestyle, and health history) that are correlated with probiotic usage to detect the improvement of probiotic responsiveness. Well-suited applications must offer rigorously designed mechanistic studies using relevant/innovative animal models or in human subjects. This NOFO is intended to support projects where potential host biological patterns that are correlated with probiotic usage have been identified, as demonstrated with supportive preliminary data, but require further mechanistic studies to test for their causality or predictability. Applicants pursuing early-stage research to identify host biological patterns that may affect probiotic health outcomes should consider the companion (R61/R33) NOFO PAR-AT-24-XXX (TEMP-25412).

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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