Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)

Does this fit your business?

This is an NIH R21 exploratory research grant for teams that can run invasive neural recording and stimulation studies in humans—meaning patients who already have electrodes implanted in the brain—to study the neural circuitry behind mental health disorders. It is for research only: dev</think>{

Best for

Universities and academic medical centers running invasive neural recording studies in humans, Small biotech or neurotech businesses with access to human invasive recording data or patients with implanted electrodes, Nonprofits and research institutes studying the neural basis of mood, emotion, cognition, or behavior, Hospitals, health systems, and government or tribal entities partnered on mental health neuroscience research

Not for

Companies or labs whose main goal is developing a new device, product, or therapy (explicitly out of scope), Researchers without access to human invasive recording or stimulation (e.g., those doing only non-invasive, animal, or纯, Retail, construction, transportation, and other industries with no neuroscience research capability

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Award range

Up to $200,000

Questions about this grant

When is the application deadline?

January 7, 2028.

How much funding can an applicant receive?

The largest single award is $200,000, and total program funding is also listed at $200,000. No cost sharing is required.

Who can apply for this grant?

Universities (public, state, and private), small businesses, for-profit organizations, nonprofits with or without 501(c)(3) status, federal, state, county, city, and special district governments, public housing authorities, school districts, and Native American tribal governments and organizations. Foreign (non-U.S.) entities, faith-based and community-based organizations, HBCUs, Hispanic-serving institutions, and Alaska Native, Native Hawaiian, and Asian American Native American Pacific Islander serving institutions are also eligible. This is an R21 exploratory research grant for invasive neural recording and stimulation studies in humans aimed at understanding neural circuitry underlying m

Can a sole proprietor or single-member LLC apply?

The facts do not say. Eligibility is listed by organization categories (universities, small businesses, for-profits, nonprofits, governments, tribal entities), and a sole proprietor or single-member LLC is not explicitly named, so check the full NOFO (PAR-25-291) on Grants.gov before assuming you qualify.

Can a nonprofit apply?

Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH R21 grants (up to $200,000) for invasive neural recording and stimulation studies in humans to advance understanding of neural circuitry underlying mental health disorders. Open to universities, small businesses, for-profits, nonprofits, governments, and tribal entities; clinical trials optional. New technology or therapy development is out of scope.

About this grant

Who can apply

Topics and uses of funds

Program contact