Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)

Does this fit your business?

This is an NIH research grant for clinical trials testing whether post-acute mental health interventions actually work over the long term, not a business grant. It fits healthcare and biotech organizations with research capacity; retail, finance, housing, and other businesses outside mental health research should not bother. Pilot-stage work belongs to a companion R34, not this program.

Best for

Healthcare and biotech organizations running mental health research, Clinical trial teams studying post-acute mental health interventions, Nonprofits, governments, tribes, and universities positioned to conduct NIH-funded clinical trials, Small businesses and for-profits with mental health research capabilities

Not for

Retail, e-commerce, finance, housing, and other businesses outside mental health research, Organizations without clinical trial capacity or mental health research focus, Applicants seeking general business operating funds or non-research grants

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for

Research, Clinical trials

Who can apply

Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?

January 7, 2028.

Who can apply for this grant?

A wide range: small businesses, for-profit organizations other than small businesses, nonprofits with or without 501(c)(3) status, county, city, township, state, and special district governments, federally and non-federally recognized tribal governments and organizations, public housing authorities, independent school districts, and public, private, and state-controlled institutions of higher education. The eligibility text also names certain other categories, including Alaska Native and Native Hawaiian Serving Institutions, HBCUs, Hispanic-serving Institutions, faith-based and community-based organizations, federal agencies, regional organizations, U.S. territories, and non-U.S. (foreign)实体

Can a sole proprietor or single-member LLC apply?

The facts do not say. The eligibility codes list small businesses and for-profit organizations generally, but they do not specifically address sole proprietors or single-member LLCs, so it is not published whether they qualify.

Can a nonprofit apply?

Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NIMH R01 grants for clinical trials evaluating effectiveness of post-acute therapeutic and service delivery interventions for mental health conditions across youth, adults, and older adults. Open to small businesses, for-profits, nonprofits, governments, tribes, and higher education institutions.

About this grant

Who can apply

Topics and uses of funds

Program contact