OpenFederal grantOpen to for-profit businessesPAR-25-181

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)

National Institutes of HealthCloses Oct 15, 2027(367 days left)

Does this fit your business?

This is an NIH research grant, not a business subsidy: it funds teams that develop and run clinical trials of new psychosocial therapies or prevention programs for mental disorders, using the experimental therapeutics approach over up to three years. If your organization does not run research studies or clinical trials, do not apply. The award amount is not published, so you cannot plan a budget from this notice alone.

Best for
Research teams at universities and medical centers, Small businesses and for-profits doing clinical R&D on mental health interventions, Nonprofits and community or faith-based organizations with research capacity, Tribal governments and organizations running mental health studies
Not for
Ordinary treatment or service providers with no research or clinical trial capability, Retail, construction, transportation, or software firms with no mental health research angle, Applicants needing a specific dollar amount up front — the award size is not published
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
77
Strong Match
Social Services & NonprofitMatches your industry (social)
72
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 15, 2027. The notice was posted November 25, 2024.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits (with or without 501(c)(3) status), city, county, state, and tribal governments, public housing authorities, independent school districts, and public or private institutions of higher education. The eligibility text also names faith-based and community organizations, certain minority-serving institutions, federal agencies, foreign organizations, and U.S. territories.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not publish rules for sole proprietors or single-member LLCs specifically, so check the full notice or ask the agency before counting on it.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without it (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH/NIMH R33 clinical trial grant to develop and test novel psychosocial therapeutic and preventive interventions for mental disorders, using experimental therapeutics to replicate target engagement and link it to clinical outcomes. Open to small businesses, for-profits, nonprofits, universities, governments, tribes, and faith-based organizations.

About this grant

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Mental health
  • Science
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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