OpenFederal grantOpen to for-profit businessesPAR-25-177

Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)

National Institutes of HealthCloses Oct 15, 2027(367 days left)

Does this fit your business?

This is an NIH research grant for full-scale clinical trials testing mental health interventions in real community and practice settings, not a business grant. It fits research teams, universities, health systems, and small businesses with clinical trial capability. Retail, construction, logistics, and any company without mental health research operations should not bother applying.

Best for
Healthcare and biotech organizations running mental health clinical trials, Nonprofits and community organizations partnering on mental health research, Universities and academic medical centers, Small businesses with clinical research capability
Not for
Retail, transportation, construction and other businesses with no mental health research capability, Organizations looking for operating funds or business expansion capital, Applicants without clinical trial experience or pilot data
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
79
Strong Match
Social Services & NonprofitMatches your industry (community)
69
Good Match
Education & TrainingMatches your industry (stem)
68
Good Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
53
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
53
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
53
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
53
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 15, 2027.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits with or without 501(c)(3) status, state, county, city and tribal governments, public housing authorities, school districts, special district governments, and public, private and state-controlled institutions of higher education. The eligibility text also lists faith-based and community-based organizations, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges, regional organizations, federal agencies, US territories, and foreign entities.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not address sole proprietors or single-member LLCs specifically.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and those without it are eligible, as long as they are not institutions of higher education.

Summary

NIH/NIMH R01 grants for full-scale hybrid effectiveness-implementation clinical trials of mental health treatment, preventive, and services interventions in community and practice settings. Eligible applicants include small businesses, for-profits, nonprofits, governments, tribes, and higher education institutions.

About this grant

Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01 Clinical Trial Required). This NOFO is a key element of NIMHs set of NOFOs to support clinical trials research across the intervention development and testing pipeline. The NOFO supports (1) clinical trials to test the effectiveness of optimized therapeutic and preventive interventions for use in community and practice settings; and (2) clinical trials to evaluate the effectiveness of patient-, provider-, organizational-, or systems-level services interventions to improve access, continuity, quality, equity, and/or value of mental health services. This NOFO is intended to support trials that: address a significant problem, such that the findings have potential to inform practice; are adequately powered to definitively answer the primary research question(s), with well-justified hypotheses supported by pilot data; and are designed to examine questions regarding mediators and moderators of effects. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support effectiveness trials that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects (i.e., the mechanism(s) that accounts for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, etc.). The collaborative R01 mechanism provides support for multisite trials when two or more sites are necessary for completion of the trial (e.g., to increase sample size, accelerate recruitment, or increase sample diversity and representation).

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Mental health
  • Research
  • Clinical trials

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

Related grants

Open opportunities funding similar work, from the same funder or in the same place.

All grantsGrants by stateGrants by industry