OpenFederal grantOpen to for-profit businessesPAR-25-285

Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Oct 15, 2027(367 days left)

Does this fit your business?

This is an NIH research grant, not a business or services grant: it funds staged studies (R61 feasibility, then R33 full trials) testing whether changes to how mental health systems are organized and delivered actually improve care. It fits research teams at health systems, clinics, schools, universities, governments, and tribes that can run clinical trials. A typical small business outside healthcare research should not bother; the award amount is not published.

Best for
Health systems and mental health clinics running research trials, Universities and research institutions, State, county, city, and tribal governments, Nonprofits and small businesses with research capability
Not for
Retail, finance, or housing businesses with no mental health research component, Organizations seeking service-delivery or operating funding rather than research funding, Applicants unable to run a clinical trial
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
82
Strong Match
Education & TrainingMatches your industry (stem)
74
Good Match
Social Services & NonprofitMatches your industry (community)
74
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureMatches your industry (infrastructure)
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, Health systems
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 15, 2027.
Who can apply for this grant?
State, county, city, township, and special district governments; federally recognized and other Native American tribal governments and organizations; nonprofits with and without 501(c)(3) status; public and private institutions of higher education; independent school districts; public housing authorities; small businesses; other for-profit organizations; and certain additional entities such as foreign organizations, faith-based and community organizations, HBCUs, Hispanic-serving institutions, and tribal colleges. Federal agencies are also eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full opportunity text (PAR-25-285) before assuming.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH-funded R61/R33 clinical trial grants to test effectiveness of mental health system interventions (organizational, policy, delivery improvements). Open to governments, tribes, nonprofits, higher ed, small businesses, and for-profit organizations; foreign entities also eligible.

About this grant

This R61/R33 concept complements NIMHs suite of clinical trial NOFOs by supporting feasibility and infrastructure development (R61) followed by well-powered clinical trials (R33) to test the effectiveness of system interventions and strategies for improving the organization, delivery, coordination, and clinical and functional outcomes of mental health services. System interventions - which may span, for example, structural, policy, organizational, and interpersonal domains - attend to issues about the access, equity, engagement/utilization, value (cost/financing), management, or quality and safety of mental health services, with the goal of improved care processes and clinical and functional outcomes. Accordingly, the focus of system interventions may include a variety of care settings, such as health systems and organizations, mental health and community clinics, schools, and child welfare or juvenile justice systems

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Mental health
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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