OpenFederal grantOpen to for-profit businessesRFA-HL-26-019

Catalyze Product Definition Medical Device prototype design/testing and disease target identification and assay development (R61/R33 - Clinical Trial Not Allowed)

National Institutes of HealthCloses Dec 23, 2027(436 days left)

Does this fit your business?

This is an NIH/NHLBI phased R61/R33 grant for early-stage translational projects: designing and testing medical device prototypes, identifying diagnostic disease targets, developing assays, and building research tools for heart, lung, blood, and sleep diseases. It fits small businesses, for-profits, universities, and nonprofits doing that specific work. Retail, finance, housing, or any organization without a medical device or diagnostic research pipeline should not bother applying.

Best for
Small businesses and for-profits developing early-stage medical device prototypes or diagnostics, Universities and academic medical centers translating HLBS research into products, Nonprofits and research organizations building assays or research tools, Tribal, state, and local government entities with translational health research programs
Not for
Businesses with no medical device, diagnostic, or HLBS research focus, Projects ready for clinical trials or human testing, Retail, finance, or housing businesses with no research component
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (medical, clinical)
89
Strong Match
Technology & SoftwareMatches your industry (innovation)
78
Strong Match
Transportation & LogisticsMatches your industry (transit)
67
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research, Prototype development, Testing
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Colleges and universities, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is December 23, 2027. The opportunity was posted on November 21, 2024.
Who can apply for this grant?
Small businesses, other for-profit organizations, nonprofits (with and without 501(c)(3) status), public and private institutions of higher education, state, county, city, and special district governments, public housing authorities, and Native American tribal governments and organizations may apply. Foreign organizations are not eligible, though foreign components of U.S. organizations are allowed.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations are eligible, so a single-member LLC structured as a small business may qualify, but the notice does not confirm this directly.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NHLBI phased R61/R33 grants for early-stage translational projects: design and test medical device prototypes, identify diagnostic disease targets, develop assays, and create research tools for heart, lung, blood, and sleep (HLBS) diseases. Small businesses, for-profits, universities, nonprofits, and state/local/tribal governments may apply; clinical trials not allowed.

About this grant

The goal of the NHLBI Catalyze Program is to provide a comprehensive suite of support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates that have been cleared for human testing, and to develop translational researchers fluent in product development and entrepreneurship. This specific Catalyze Product Definition initiative will provide the early stage translational support needed for the activities required to develop and test device prototypes, identify diagnostic disease targets and develop associated assays, and develop research tools to treat HLBS diseases and disorders. This is a phased initiative for early stage projects. The R61 phase provides support to identify and test initial prototype designs, to identify a disease target and generate experimental design, and to identify, test and pilot research tools. The R33 phase provides support for continued prototype development and testing, in addition to modifying design features and user feedback, diagnostic product generation, exploration of assay components, and characterization of a load design, and research tool improvement, large trial testing and data integration. Following successful completion of the program, it is expected that the potential products will be poised to move forward for in vivo testing (optimization, safety, efficacy) with additional support from NIH and/or other federal and private programs. This initiative has a companion initiative that supports development of therapeutics and combination products and is also part of a suite of innovation grants to advance projects to the point where they can meet the entry criteria for the NHLBI Catalyze Preclinical Program.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Medical devices
  • Research
  • Technology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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