OpenFederal grantOpen to for-profit businessesPAR-25-122

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

National Institutes of HealthCloses Nov 16, 2027(399 days left)Up to $100,000

Does this fit your business?

This is an NIH R03 pilot grant for basic biochemical and biological research on understudied proteins linked to rare diseases, meant to generate preliminary data and research tools. It fits labs and small research businesses that can do bench science on proteins from the eligible list; it is not for companies outside biomedical research, and clinical trials are not allowed. Note: the matching engine flags this as primarily for minority-owned businesses, but the program facts name no such set-ASD

Best for
Biomedical research labs at universities and nonprofits, Small biotech or for-profit research companies, Researchers generating preliminary data on understudied rare-disease proteins, Institutions studying druggable proteins tied to rare diseases
Not for
Businesses outside biomedical research, such as construction, retail, or logistics firms, Clinical trials or patient-care projects (clinical trials are not allowed), Organizations without the lab capacity to do basic protein research
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
62
Good Match
Environment & ConservationLimit: Primarily for minority-owned businesses
48
Possible Match
Technology & SoftwareLimit: Primarily for minority-owned businesses
48
Possible Match
Energy & Clean TechLimit: Primarily for minority-owned businesses
45
Possible Match
Agriculture & FarmingLimit: Primarily for minority-owned businesses
42
Possible Match
Housing & Real EstateLimit: Primarily for minority-owned businesses
42
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
ManufacturingLimit: Primarily for minority-owned businesses
42
Possible Match
Social Services & NonprofitLimit: Primarily for minority-owned businesses
42
Possible Match
Education & TrainingLimit: Primarily for minority-owned businesses
41
Possible Match
Arts & CultureLimit: Primarily for minority-owned businesses
40
Possible Match
Food & BeverageLimit: Primarily for minority-owned businesses
40
Possible Match
Finance & BankingLimit: Primarily for minority-owned businesses
39
Possible Match
Retail & E-CommerceLimit: Primarily for minority-owned businesses
37
Possible Match
Transportation & LogisticsLimit: Primarily for minority-owned businesses
35
Possible Match
Construction & InfrastructureLimit: Primarily for minority-owned businesses
34
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $100,000

Questions about this grant

When is the application deadline?
The application deadline is November 16, 2027.
How much funding can an applicant receive?
The largest award is $100,000. These are NIH R03 pilot grants meant to fund basic biochemical and/or biological work and generate preliminary data or tools.
Who can apply for this grant?
Universities (public, state-controlled, and private), nonprofits with and without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, state, county, city, and special district governments, federally recognized and other Native American tribal governments and organizations, public housing authorities, independent school districts, and certain other institutions such as HBCUs, Hispanic-serving institutions, and Alaska Native and Native Hawaiian Serving Institutions. Foreign organizations are not eligible, and non-domestic components of U.S. organizations cannot apply.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility text lists small businesses and for-profit organizations among eligible applicants, but it does not specifically address sole proprietors or single-member LLCs.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH R03 pilot grants (up to $100k) for basic biochemical/biological research generating preliminary data and tools on understudied druggable proteins linked to rare diseases. Open to universities, nonprofits, small businesses, for-profits, state/local/tribal governments, and other eligible organizations; clinical trials not allowed.

About this grant

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Science
  • Rare diseases
  • Biomedical research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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