OpenFederal grantOpen to for-profit businessesPAR-25-024

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH research grant for discovering and early-evaluating biomarkers for neurological and neuromuscular disorders, and it requires preliminary human evaluation, not just animal or lab work. It fits research-driven universities, biotech companies, and nonprofits with clinical samples or datasets. Retailers, software firms, and any business without a research operation should not bother applying.

Best for
Universities and academic research centers, Small biotech or life-science companies, Nonprofit research organizations, Clinical research teams with access to human samples or datasets
Not for
Businesses with no research or clinical development capability, Retail, finance, housing, and other companies outside healthcare and biotech, Organizations without access to human samples or datasets
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Colleges and universities, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is January 7, 2028.
Who can apply for this grant?
Eligible applicants include public and private institutions of higher education, small businesses, for-profit organizations other than small businesses, nonprofits with or without 501(c)(3) status, state and local governments, independent school districts, public housing authorities, and federally recognized and other Native American tribal governments and organizations. Foreign organizations and non-U.S. components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check the full announcement before assuming you can apply.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH R61/R33 award supporting discovery and early evaluation of candidate biomarkers or biomarker signatures for neurological and neuromuscular disorders, including animal studies plus preliminary human evaluation, to prepare tools for neurotherapeutic clinical development. Eligible applicants include universities, small businesses, for-profit organizations, nonprofits, and state, local, and tribal

About this grant

The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Topics and uses of funds

Topics

  • Health
  • Science
  • Biomarkers
  • Neurology
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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