OpenFederal grantOpen to for-profit businessesPAR-25-225

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies (R61/R33 Clinical Trial Not Allowed)

National Institutes of HealthCloses Oct 20, 2027(372 days left)

Does this fit your business?

This is an NIH/NINDS research grant for preclinical testing of drug candidates — small molecules or biologics — aimed at neurological or neuromuscular disorders, specifically pharmacodynamic, pharmacokinetic, and in vivo efficacy studies. It fits small biotech and research organizations with a therapeutic candidate already in hand; it does not fund clinical trials, so companies past the preclinical stage or without a neuroscience focus should not bother. Money amounts are not published.

Best for
Small businesses developing small-molecule or biologic therapeutics for neurological or neuromuscular disorders, Biotech companies running pharmacodynamic, pharmacokinetic, or in vivo efficacy studies, Universities and nonprofits with preclinical neuroscience drug-development programs
Not for
Clinical-stage projects seeking to run human trials, Businesses with no neuroscience or neuromuscular drug-development work, Organizations looking for general operating or commercialization funding
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (technology, tech, innovation)
77
Strong Match
Healthcare & BiotechMatches your industry (clinical)
76
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 20, 2027.
Who can apply for this grant?
Small businesses, for-profit organizations other than small businesses, nonprofits (with or without 501(c)(3) status), private and public institutions of higher education, state, county, city, township, and special district governments, federally recognized tribal governments, tribal organizations, independent school districts, and public or Indian housing authorities. Foreign organizations and certain other entities listed in the eligibility text may also apply.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify as small businesses for this program.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH/NINDS IGNITE grants fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies of therapeutic agents (small molecules, biologics) for neurological or neuromuscular disorders. Eligible applicants include small businesses, for-profits, universities, nonprofits, and state/local/tribal governments; clinical trials not allowed.

About this grant

Reissue PAR-21-122. This NOFO provides funding to conduct pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to demonstrate that proposed therapeutic agent(s) have sufficient biological activity to warrant further development to treat neurological or neuromuscular disorders that fall under the NINDS mission. Therapeutic agents include small molecules, biologics or biotechnology-derived products. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for the Blueprint Neurotherapeutics Network or other translational programs.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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