OpenFederal grantOpen to for-profit businessesPAR-25-273

Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

National Institutes of HealthCloses Jan 7, 2028(451 days left)Up to $200,000

Does this fit your business?

This is an NIH R21 grant for research teams that develop, improve, or preserve animal models and related biological materials for biomedical research relevant to human health. Your project must have broad applicability across multiple NIH institutes; single-disease or single-institute projects will be withdrawn. If you are not doing biomedical research infrastructure work, do not apply.

Best for
Biomedical research labs at universities and nonprofits, Small businesses and for-profits developing animal models or research tools, Research teams whose work spans multiple NIH institutes
Not for
Businesses with no biomedical research focus, Projects aimed at a single disease or a single NIH institute
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, medical, biomedical, clinical)
93
Strong Match
Technology & SoftwareMatches your industry (tech)
74
Good Match
Education & TrainingMatches your industry (stem)
73
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureMatches your industry (infrastructure)
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $200,000

Questions about this grant

When is the application deadline?
The application deadline is January 7, 2028.
How much funding can an applicant receive?
The largest award is $200,000, and total program funding is $200,000. No cost sharing is required.
Who can apply for this grant?
Universities, nonprofits (with or without 501(c)(3) status), small businesses, other for-profit companies, state and local governments, tribes, and certain other organizations such as HBCUs and Hispanic-serving institutions can apply. Foreign organizations are not eligible, and non-U.S. components of U.S. organizations cannot apply either.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses and for-profit organizations are eligible, but the notice does not specifically address sole proprietors or single-member LLCs, so check with NIH before assuming you qualify.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are both listed as eligible applicants.

Summary

NIH R21 grants to develop, improve, characterize, and preserve animal models and related biological materials, technologies, and new approach methodologies for biomedical research relevant to human health and disease. Open to universities, nonprofits, governments, tribes, and businesses; projects must have broad applicability across NIH institutes.

About this grant

This notice of funding opportunity (NOFO) encourages innovative research to develop, improve, characterize, and preserve animal models as well as animal model related biological materials, technologies, and new approach methodologies (NAMs) for studies relevant to human health and disease. This NOFO also seeks projects aimed at improving the diagnosis and control of diseases that could confound or interfere with animal use in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include animal models and explore multiple body systems or multiple categories of diseases. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC, will be considered not acceptable to this NOFO and will be withdrawn.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Topics and uses of funds

Topics

  • Science
  • Health
  • Biomedical research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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