OpenFederal grantOpen to for-profit businessesPAR-25-145

Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

National Institutes of HealthCloses Jan 7, 2028(451 days left)

Does this fit your business?

This is an NIH R01 research grant for studies on long-term adverse effects of cancer therapy—mechanisms, clinical characterization, and biomarkers for future intervention trials. It fits research-active universities, nonprofits, governments, tribes, and for-profits including small businesses with real clinical or translational research capability. Retail, finance, housing, or any business without a cancer research program should not bother applying.

Best for
Universities and academic medical centers running cancer research labs, Nonprofits and foundations focused on cancer or clinical research, Biotech and small businesses developing cancer therapy or biomarker tools, State, local, and tribal entities with research capacity
Not for
Retail, finance, housing, or other businesses with no cancer research connection, Organizations without research capability or clinical/scientific staff, Applicants seeking general business operating funds or startup capital
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
88
Strong Match
Technology & SoftwareMatches your industry (sttr)
76
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
January 7, 2028.
Who can apply for this grant?
A wide range: public and private institutions of higher education, nonprofits with or without 501(c)(3) status, state and local governments, federally recognized and other Native American tribal governments and organizations, public housing authorities, independent school districts, for-profit organizations other than small businesses, and small businesses. The eligibility text also lists foreign (non-U.S.) entities, HBCUs, Hispanic-serving institutions, and other specified institutions.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not spell out whether a sole proprietor or single-member LLC qualifies, so that is not published here.
Can a nonprofit apply?
Yes. Both nonprofits having 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH R01 grants for collaborative basic, translational, and clinical research on long-term adverse effects of cancer therapies—identifying mechanisms, clinically characterizing sequelae, and validating biomarkers/endpoints for future intervention trials. Open to universities, nonprofits, governments, tribes, and for-profit organizations including small businesses.

About this grant

The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects. This FOA supports basic, translational, and clinical research projects that seek to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches to prevent or minimize the development of long-term sequelae. Research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints (biomarkers, imaging, patient-reported outcomes, or combined elements) for future use in clinical trials that will evaluate the efficacy of interventions designed to prevent or reduce specific adverse sequelae.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Cancer
  • Clinical research
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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