OpenFederal grantOpen to for-profit businessesPAR-24-293

Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

National Institutes of HealthCloses Aug 18, 2027(309 days left)

Does this fit your business?

This NIH program funds preclinical discovery and development of biologic-based therapeutics for nervous system disorders, from lead optimization through Phase I clinical testing. It is for biotech and life-science organizations with a real drug-development pipeline, not for companies in construction, retail, or finance, where nothing in the notice points to their needs. Award amounts are not published.

Best for
Biotech and life-science companies developing biologic drugs for nervous system disorders, Small businesses and for-profits running preclinical discovery through Phase I testing, Universities and research institutions with biologic therapeutic candidates, Nonprofits and government or tribal entities with nervous-system drug development programs
Not for
Businesses outside biotech or nervous-system drug development, Organizations with no capacity for preclinical research or clinical trials, Applicants seeking general operating funds or non-research projects
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
84
Strong Match
Technology & SoftwareMatches your industry (technology, tech)
82
Strong Match
Education & TrainingMatches your industry (stem)
71
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingMatches your industry (manufacturing)
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
53
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is August 18, 2027.
Who can apply for this grant?
Small businesses, for-profit organizations, nonprofits with or without 501(c)(3) status, public and private institutions of higher education, state, local, county, and tribal governments, public housing authorities, independent school districts, and special district governments may apply. Other eligible applicants include foreign organizations, faith-based and community-based organizations, and various minority-serving institutions.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses and for-profit organizations are eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify, so check with NIH directly.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH program funding preclinical discovery and development of biologic-based therapeutics for nervous system disorders, from lead optimization through Phase I clinical testing. Small businesses, for-profits, nonprofits, universities, and governments may apply; awardees retain IP rights.

About this grant

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Biotechnology

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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