OpenFederal grantOpen to for-profit businessesPAR-25-053

Translational Neural Devices (R61/R33 - Clinical Trial Optional)

National Institutes of HealthCloses Jan 28, 2027(107 days left)

Does this fit your business?

This NIH program funds translational development of therapeutic and diagnostic devices for nervous system and neuromuscular disorders, from prototype implementation through safety testing, IDE/IRB approval, and small clinical studies. It is for organizations with a device already far enough along to justify clinical work, not early-stage research or general health projects. Retail, finance, housing, and other unrelated businesses should not bother applying.

Best for
Small businesses developing therapeutic or diagnostic devices for nervous or neuromuscular system disorders, For-profit companies with a clinical prototype device ready for safety testing and small clinical studies, Nonprofits and universities pursuing translational neural device development, Teams preparing IDE or IRB approvals for device studies
Not for
Businesses with no device, prototype, or clinical development work underway, Retail, finance, housing, and other industries with nothing in this notice pointing to them, Organizations seeking funding for basic research or non-device health projects
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Education & TrainingMatches your industry (stem)
77
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Clinical trials, Device development, Prototype development, Safety testing, Regulatory approval
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is January 28, 2027.
Who can apply for this grant?
Small businesses, for-profit organizations other than small businesses, nonprofits (both with and without 501(c)(3) status), state, county, city, township, and special district governments, independent school districts, federally recognized and other Native American tribal governments and organizations, public and private institutions of higher education, public housing authorities, and certain other entities such as faith-based organizations, foreign organizations, and serving institutions listed in the eligibility text.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility codes list small businesses and for-profit organizations other than small businesses, but they do not specifically address sole proprietors or single-member LLCs, so check the full NOFO or contact NIH before assuming you qualify.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH cooperative agreement supporting translational development of therapeutic and diagnostic devices for nervous/neuromuscular system disorders. Funds clinical prototype implementation, non-clinical safety/efficacy testing, design verification, IDE/IRB approval, and small clinical studies. Open to small businesses, for-profits, nonprofits, governments, tribes, and higher education institutions.

About this grant

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This NOFO is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.

Who can apply

Other Eligible Applicants include the following:

Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Medical devices
  • Neuroscience
  • Translational research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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