OpenFederal grantOpen to for-profit businessesRFA-AI-27-014

Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)

National Institutes of HealthCloses Oct 9, 2028(727 days left)

Does this fit your business?

This is an NIH research grant (U01) for developing medical countermeasures, diagnostics, biomarkers, and injury models for radiological/nuclear or chemical emergencies. It fits biotech and research organizations doing laboratory R&D; clinical trials are not allowed. Retail, finance, housing, and any business without a serious research operation should not bother, and foreign entities or projects with foreign subawards are barred.

Best for
Biotech and life-science companies developing diagnostics, biomarkers, or radiation/chemical injury countermeasures, Small businesses and for-profits doing R&D on medical countermeasures, Universities and research institutions studying radiation or chemical injury, Nonprofits and government or tribal entities running relevant research programs
Not for
Retail, finance, housing, and other businesses with no medical or scientific R&D role, Foreign organizations or U.S. organizations planning foreign subawards, Projects requiring clinical trials — this U01 does not allow them
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, medical, clinical)
94
Strong Match
Technology & SoftwareMatches your industry (tech)
75
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
October 9, 2028. The notice was posted September 1, 2026, so the window is long.
Who can apply for this grant?
Small businesses, for-profit organizations other than small businesses, nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, state, county, city, and special district governments, federally recognized tribal governments and tribal organizations, independent school districts, public housing authorities, and other domestic organizations. Foreign entities are not eligible, and applications with foreign subawards or subcontracts will not be considered.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are eligible, but the notice does not spell out whether sole proprietors or single-member LLCs qualify; check Section III of the NOFO.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without it (other than institutions of higher education) are listed as eligible.

Summary

NIH research grants (U01, clinical trials not allowed) to study radiation/chemical injury, develop biomarkers, diagnostics, and medical countermeasures for radiological/nuclear or chemical public health emergencies. Eligible: small businesses, for-profits, nonprofits, universities, state/local/tribal governments, and other domestic organizations; foreign entities not eligible.

About this grant

The purpose of this notice of funding opportunity (NOFO) is to support research that advances understanding of the natural history of radiation or chemical exposures; develops relevant injury models; identifies and validates diagnostic tools, biomarkers, or triage technologies; and supports the development of effective medical countermeasures (MCMs) to mitigate or treat acute and/or delayed injuries resulting from radiological/nuclear or chemical public health emergencies.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Topics and uses of funds

Topics

  • Health
  • Science
  • Defense
  • Emergency preparedness

Program contact

National Institutes of HealthRADCHEM_U01@mail.nih.gov301-402-2541

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