OpenFederal grantOpen to for-profit businessesPAR-27-053

Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

National Institutes of HealthCloses Jun 16, 2028(612 days left)

Does this fit your business?

This is an NIH research grant for exploratory clinical studies of the brain mechanisms behind substance use disorders, structured as a two-phase R61/R33 award. It fits research organizations with neuroscience and clinical capability, not businesses looking for general operating money. Retail, finance, housing, and other firms with no research operation should not bother applying.

Best for
Research teams studying the neuroscience of substance use disorders, Universities and academic medical centers, Nonprofits with clinical research programs, Small biotech or for-profit research firms
Not for
Businesses with no research or clinical operations, Projects that are not exploratory clinical research on substance use disorders, Applications relying on foreign subawards or subcontracts
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
82
Strong Match
Technology & SoftwareMatches your industry (innovation)
74
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
June 16, 2028.
Who can apply for this grant?
State, county, city and township governments, special districts, public housing authorities, independent school districts, federally recognized and other Native American tribal governments and organizations, public and private higher education institutions, nonprofits with or without 501(c)(3) status, for-profit organizations other than small businesses, and small businesses may all apply. Foreign organizations and foreign components of U.S. organizations are also eligible, but applications involving foreign subawards or subcontracts will be rejected.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not spell out how sole proprietors or single-member LLCs are treated, so check Section III of the NOFO.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible.

Summary

NIH R61/R33 phased innovation awards for exploratory clinical research on the neurobiological mechanisms of substance use disorders. Eligible applicants include state/local governments, tribal organizations, higher education institutions, nonprofits, for-profit organizations, and small businesses. Funds support clinical research studies; clinical trials optional.

About this grant

This notice of funding opportunity (NOFO) uses a R61/R33 Phased Innovation Award activity code to support clinical research applications that are exploratory and developmental in nature and focus on understanding the neurobiological mechanisms underlying substance use disorders (SUD), including fundamental circuitry and behavior relevant to substance use. For projects not requiring a phased research approach, applicants are encouraged to apply under a different funding activity code (e.g., PA-25-305 "Research Project Grant (Parent R01 Clinical Trial Required)" or its subsequent reissue).

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Topics and uses of funds

Topics

  • Health
  • Science
  • Neuroscience
  • Substance abuse

Program contact

National Institutes of HealthNIDA_DNB_BCNB_r61@nih.gov301-402-2541

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