OpenFederal grantOpen to for-profit businessesRFA-CA-27-005

Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)

National Institutes of HealthCloses Jan 11, 2027(90 days left)Up to $700,000

Does this fit your business?

This is an NIH/NCI program for teams developing drug therapies for adult glioblastoma, taking agents from late pre-clinical work through IND studies into early Phase 0/1 human trials. It fits biotech and cancer research organizations; retail, finance, housing, software, or any business with no drug-development pipeline should not bother applying. Foreign organizations and foreign components of U.S. organizations are not eligible.

Best for
Biotech and drug-development companies with a glioblastoma agent in late pre-clinical development, Cancer research nonprofits and 501(c)(3) organizations, Universities and academic medical centers running early-phase clinical trials, Collaborative teams able to carry a therapy through IND-enabling work into Phase 0/1 trials
Not for
Businesses outside healthcare and biotech with no brain-drug pipeline, Organizations planning to use the funds for anything other than GBM therapy R&D, Foreign entities or U.S. organizations with foreign components
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
80
Strong Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Transportation & LogisticsMatches your industry (transit)
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $700,000

Questions about this grant

When is the application deadline?
January 11, 2027.
How much funding can an applicant receive?
The largest single award is $700,000, with total program funding of $4,400,000 and about 4 awards expected. No per-award minimum is published.
Who can apply for this grant?
Small businesses, other for-profit organizations, nonprofits with or without 501(c)(3) status, private and public institutions of higher education, state, county, city, township and special district governments, independent school districts, public and Indian housing authorities, and Native American tribal governments and tribal organizations. Foreign organizations, foreign components of U.S. organizations, and non-domestic components are not eligible. Check Section III of the NOFO for the full eligibility details.
Can a sole proprietor or single-member LLC apply?
The published eligibility list does not name sole proprietors or single-member LLCs. Small businesses are eligible, so a single-member LLC that qualifies as a small business may fit, but confirm your structure against Section III of the NOFO before applying.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are both listed as eligible, other than institutions of higher education.

Summary

NIH/NCI funds a collaborative Glioblastoma Therapeutics Network to develop novel brain-penetrating therapies for adult glioblastoma, moving agents from late pre-clinical development through IND studies into early Phase 0/1 clinical trials. Eligible applicants include small businesses, other for-profits, nonprofits, higher education institutions, state/local/tribal governments, and others; foreign,

About this grant

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms. To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through investigational new drugs (IND) studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of HealthGTN-contacts@nih.gov301-402-2541

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