OpenFederal grantOpen to for-profit businessesPAR-25-101

Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

National Institutes of HealthCloses Aug 11, 2027(302 days left)Up to $150,000

Does this fit your business?

This is an NIH/NIDA research grant for highly innovative, high-risk basic research on the causes, prevention, or treatment of substance use disorders, capped at $150,000. It is for research teams with transformative, unconventional hypotheses or novel techniques, not for businesses seeking operating capital or commercialization funding. If your organization does not conduct scientific research on substance use disorders, do not bother applying.

Best for
Research teams studying substance use disorders, Small businesses and for-profits doing basic biomedical or tech research, Universities and hospitals with high-risk, high-impact research ideas, Nonprofits with scientific research programs
Not for
Businesses looking for operating capital or commercialization funding, Organizations with no research capacity or no connection to substance use disorders, Applicants needing awards above $150,000
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (clinical)
74
Good Match
Technology & SoftwareMatches your industry (tech)
72
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureMatches your industry (creative)
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
53
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
52
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
52
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
Up to $150,000

Questions about this grant

When is the application deadline?
The application deadline is 2027-08-11.
How much funding can an applicant receive?
The largest award is $150,000, and total program funding is $150,000. There is no cost sharing requirement.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations, nonprofits, public and private institutions of higher education, state governments, county and city governments, independent school districts, special district governments, public housing authorities, and Native American tribal governments and organizations. Other eligible entities include foreign organizations, faith-based and community-based organizations, HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and U.S. territories.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations are listed as eligible, but the notice does not publish rules for these specific business structures.
Can a nonprofit apply?
Yes. Both nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are listed as eligible applicants.

Summary

NIH/NIDA R21 award for highly innovative, high-risk basic research on the etiology, pathophysiology, prevention, or treatment of substance use disorders, including novel techniques or transformative hypotheses. Eligible applicants include small businesses, for-profit organizations, nonprofits, universities, state/local/tribal governments, and other entities; ceiling $150,000.

About this grant

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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