OpenFederal grantOpen to for-profit businesses26-511

NSF Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs: A Pilot Emphasis on Scientific Instrumentation

U.S. National Science FoundationCloses Nov 4, 2026(22 days left)

Does this fit your business?

This is NSF's SBIR/STTR pilot for US small businesses and startups building next-generation scientific instrumentation, novel experimental platforms, and scientific equipment. It is for deep-tech R&D companies, not service firms or nonprofits; if your business does not develop scientific instruments or experimental platforms, do not bother applying. NSF takes no equity and awardees keep their IP.

Best for
US small businesses and startups developing next-generation scientific instrumentation, Companies building novel experimental platforms or scientific equipment, Deep-tech R&D ventures in technology and software, Small businesses pursuing Phase I, Phase II, or Fast-Track SBIR/STTR awards
Not for
Nonprofits and organizations without a for-profit small business structure, Companies whose work is not scientific instrumentation, experimental platforms, or scientific equipment, Businesses whose PI cannot commit primary employment to the company during the award
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareMatches your industry (technology, tech, innovation, sbir, sttr)
100
Strong Match
Finance & BankingMatches your industry (economic, business)
85
Strong Match
Construction & InfrastructureMatches your industry (infrastructure)
78
Strong Match
Retail & E-CommerceMatches your industry (small business, economic)
74
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Healthcare & BiotechLimit: Nothing in this notice points to healthcare & biotech
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Arts & CultureLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Education & TrainingLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Environment & ConservationLimit: This program does not accept nonprofit applicants.
0
Worth Exploring
Social Services & NonprofitLimit: This program does not accept nonprofit applicants.
0
Worth Exploring

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
Small businesses

Questions about this grant

When is the application deadline?
November 4, 2026.
Who can apply for this grant?
US small businesses and startups developing next-generation scientific instrumentation, novel experimental platforms, and scientific equipment. The Principal Investigator's primary employment (at least 51 percent) must be with the small business for the duration of the award, and the PI must have the legal right to work in the United States. There are no PI degree requirements.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility text names small businesses as eligible applicants but does not address sole proprietors or single-member LLCs specifically.
Can a nonprofit apply?
No. This program does not accept nonprofit applicants.

Summary

NSF SBIR/STTR pilot for US small businesses and startups developing next-generation scientific instrumentation, novel experimental platforms, and scientific equipment. Phase I, Phase II, and Fast-Track awards up to $2.0 million per company for R&D; NSF takes no equity and awardees keep IP ownership.

About this grant

NSF invests in scientific discoveries, technological breakthroughs, and transformative innovations that strengthen economic growth, enhance security, and improve the lives of Americans and people around the world. Our ability to support that mission requires a robust scientific and engineering (S&E) enterprise in the United States that allows scientists to innovate at the frontier. In addition to funding scientists, America needs next-generation scientific instrumentation that allows scientists to pursue new innovations. In many fields, it is critical that this new scientific instrumentation is developed in the United States.

In support of this mission, NSF is initiating a pilot emphasis area for its SBIR/STTR programs to invest in startups and small businesses that are specifically developing enabling technologies that include next-generation instrumentation, novel experimental platforms, and other scientific equipment to advance the frontiers of scientific discovery and strengthen the American scientific and engineering enterprise. This encompasses novel instrumentation necessary for the coming era of AI-driven discoveries. This pilot will prioritize investing in the necessary infrastructure to support entirely new fields of scientific discovery, making new technological breakthroughs and transformative applications possible. Through this approach, NSF will continue to lead in propelling the scientific enterprise to new frontiers.

This pilot emphasis area for the NSF SBIR/STTR programs funds across enabling technology areas and market sectors in alignment with the above goals; the programs do not solicit specific technologies for the purpose of procuring goods and services for the agency from startups and small businesses.

NSF will continue to invest in other deep-tech ventures through the historic NSF SBIR/STTR programs available here.

Funding opportunities are available through the NSF SBIR/STTR programs: Phase I, Phase II, Fast-Track, and Supplements. Each company can receive up to $2.0 million for R&D. Separately, NSF welcomes Strategic Breakthrough proposals, upon recommendation from the Program Officer, for Phase II awardees. NSF takes no equity and awardees keep full ownership of their company and intellectual property.

Expanding Participation in STEM and Gold Standard Science:

NSF prioritizes cutting-edge discovery science and engineering research, advancing technology and innovation, and creating opportunities for all Americans. NSF also expects the highest standards of scientific rigor, integrity and adherence to tenets of Gold Standard Science in proposals, as appropriate for the field of science and research modality.

Who can apply

Who May Serve as PI:

Who May Serve as PI: The primary employment of the Principal Investigator (PI) must be with the small business at the time of award and for the duration of the award, unless a new PI is named. Primary employment is defined as at least 51 percent employed by the small business. NSF normally considers a full-time work week to be 40 hours and considers employment elsewhere greater than 19.6 hours per week to conflict with this requirement. Occasionally, deviations from this requirement may occur, and must be approved in writing by the Funding Agreement program officer after consultation with the agency SBIR/STTR program manager/coordinator.

The PI must have a legal right to work for the proposing company in the United States, as evidenced by citizenship, permanent residency, or an appropriate visa. The PI does not need to be associated with an academic institution. There are no PI degree requirements (i.e., the PI is not required to hold a Ph.D. or any other degree). A PI must devote a minimum of one calendar month of effort per six months of performance to an NSF SBIR/STTR Phase I project.

 

The PI must devote the following levels of effort:

For Phase I: a minimum of one calendar month per six months of performance

For Phase II: a minimum of one calendar month per six months of performance

For Fast-Track: a minimum of three calendar months per six months of performance. 

Topics and uses of funds

Topics

  • Science
  • Technology
  • Economic development

Program contact

U.S. National Science Foundationgrantsgovsupport@nsf.gov703-292-4203

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